By Walter Last
Pyroluria is a common metabolic condition in which pyrrole, a key component of haemoglobin, is overproduced in the liver. The surplus binds to vitamin B6 and zinc and is excreted in the urine. This creates severe deficiencies in B6 and zinc and to a lesser degree in some other nutrients, such as niacinamide, gamma linolenic acid (GLA), biotin, and sometimes manganese, also other B-vitamins may be low.
Depending on conditions, this may be a leading cause not only of Type 1 diabetes but also of most mental-emotional problems. The main cause of pyroluria appears to be intestinal dysbiosis with overgrowth of Candida, pleomorphic (shape-changing) microbes in the blood, and possibly Lyme disease, which may invade the liver and affect its functions. Due to the overuse of antibiotics and other drugs presently the original cause tends to be the fungal form of Candida, often in combination with related microbes. These are able to change the genetic material in liver cells so that this condition can then be inherited and often runs in families.
The more serious conditions commonly arise from an uncontrolled Candida problem coming on top of inherited pyroluria. Candida toxins absorbed mainly from the intestines (e.g. acetaldehyde, tartaric acid, and arabinose, an abnormal 5-carbon sugar, disable mainly the energy production in brain and muscles, thereby re-enforcing similar problems caused by the vitamin B6 and zinc deficiency caused by pyroluria. This partnership between inherited pyroluria and acquired Candida problems in combination with Leaky Gut Syndrome underlies most of our modern diseases.
The resulting vitamin and mineral deficiencies may initially require a high intake of these vitamins, although biotin can be obtained from egg yolk, while gamma linolenic acid is highest in spirulina. With pyroluria the liver often cannot convert normal vitamin B6 or pyridoxine into the activated form Pyridoxal-5-Phosphate or P5P which should then be supplemented.
The following includes the most common symptoms associated with Pyroluria. Not all of these are present in everyone with pyroluria. If there is poor dream recall which does not greatly improve by taking 50mg or more of vitamin B6 as pyridoxine, then I would strongly suspect pyroluria, and supplement with P5P and high doses of zinc, especially if also several other of the listed symptoms are present. Start with 50mg of P5P and 30 – 40mg of zinc – half a crushed or chewed up tablet of each at the start of breakfast and lunch.
Gradually over several weeks increase both P5P and zinc to an optimal dose at which most symptoms start improving or disappear. In mild conditions this my be almost immediately even with the initial dose, in severe cases much higher doses may be needed for several month before good progress is made. Initially too much P5P may cause overstimulation or bouts of overactivity in children, and difficulty falling asleep, especially if taken in the evening. Also cleansing reactions may occur, temporarily causing skin problems.
In addition to providing missing nutrients also focus on intestinal sanitation, anti-Candida therapy, and cleansing and activating the liver. All problems are much worse if there is in addition mercury toxicity. Even without pyroluria body builders prefer P5P because of its superior qualities in building muscles. The FDA has been petitioned by a drug company to ban the sale of P5P as it did previously with another form of vitamin B6, pyridoxamine. Health agencies in other countries may follow. Therefore it may be prudent to stock up on it. Individuals with serious pyroluria may need it for the rest of their lives.
1. Poor dream recall (vitamin B6 deficiency)
2. White spots on finger nails (zinc deficiency)
3. Morning nausea, poor morning appetite, tendency to skip breakfast
4. Type 1 diabetes, epilepsy (B6 and zinc deficiency)
5. Pale skin, poor tanning, burns easily in the sun
6. Sensitivity to bright light (vitamin B2 deficiency)
7. Hypersensitive to loud noises (magnesium deficiency)
8. Reading difficulties (e.g. dyslexia)
9. Poor ability to cope with stress (vitamin B5 helps)
10. Mood swings or temper outbursts
11. Histrionic (dramatic) tendency
12. Argumentative, enjoys argumenting
13. New situations or changes in routine are stressful (i.e. travelling)
14. Much higher capability and alertness in the evening than in the morning
15. Poor short term memory, dementia
16. Abnormal body fat distribution
17. Rheumatoid arthritis (also needs boron/borax)
18. Dry or aging skin
19. Anxiousness or shyness
20. Reaching puberty later than normal
21. Difficulty digesting, especially proteins
22. Tendency toward being a loner or avoiding larger groups of people
23. Stretch marks on skin (zinc deficiency)
24. Poor sense of smell or taste (zinc deficiency)
25. Feel uncomfortable with strangers
26. Frequently experience fatigue, low energy
27. Tendency to overreact to tranquilizers, barbiturates, alcohol or other drugs
28. A tendency toward anaemia and allergies
29. History of mental illness, addictions or alcoholism in family
30. Easily upset by criticism
31. Sweet or fruity smell of breath or sweat when ill or stressed
32. Prone to acne, eczema or psoriasis
33. Tendency toward feeling anxious, fearful, lifelong inner tension
34. Difficulty recalling past events or people
35. Bouts of depression or nervous exhaustion
36. Prone to frequent colds or infections
37. Sun sensitivity and burns easily
38. Paresthesia (tingly sensations mainly in the extremities)
39. Poor muscle development and poor connective tissue
40. Eye, pancreas and liver problems
41. Thyroid, parathyroid and adrenal problems
42. Mental diseases and emotional problems
43. Hormonal imbalances, low enzyme activity
44. Cold hands and feet, Carpal Tunnel Syndrome
45. Problems with fingers and hands (B6 deficiency)
46. Symptoms of Candida